82 points Anon84 2 hours ago 94 comments

squidmaster 1 hour ago | parent

> Before injecting this cocktail into your bloodstream, would you want to know that there is at least one human cancer researcher who understands the mechanism behind this cure.

Tao is out of his lane; lots of medicines don't have understood mechanisms. We don't even have the mechanisms behind general anesthesia nailed down; do you want to forgo it when the docs cut you open to remove your tumors?

gste 27 minutes ago | parent

Indeed, aren't medical trials based on its effects, rather than how it works?

Would you prefer to take the medicine that is proven to work or the one that is quite interesting for academic reasons behind its understood mechanisms but doesn't actually work?

Tanjreeve 19 minutes ago | parent

Some mechanism of particular substrates being effective on a condition (commonly when a medicine is repurposed) not being fully understood is not the same as just guessing with a medical compound. AI boosters keep coming out with this line but it's basically wordplay to conflate the clinical/biomedical version of "not fully understood" with the LLM industry version of "not fully understood"

ijk 18 minutes ago | parent

AI has been turning computer science into biology for the past decade or so. By which I mean that things like neural networks need to be investigated empirically, constructing methodologies and instruments that more closely resemble how fields like biology and medicine have to probe the very complex and messy reality that is beyond our current capacity to fully express in symbolic precision.

Now math gets to deal with that same reckoning. They were already well on their way there with previous Lean proofs, but this has pushed things beyond that horizon and I'm not sure some of the mathematicians are ready for it.

19298857 59 minutes ago | parent

It is nice to see some sanity back in the conversation!

I'm still not sure about math-2.0 (humans+AI will make fundamentally more progress):

- AI and computer usage take a mental toll on humans and humans will overlook radical improvements.

- AI may be good at finding useless things like "P==NP, but the complexity is O(n**4242424242424242)". In other words, useless.

- Humans become formalists and lose traditional sources of inspiration. Maybe interacting with Lean should be left to specialists, but not to creative blackboard mathematicians.

- AI exposure will further intellectual conformity, more than the Internet did.

As to the last point, a lot of progress (real, not measured in publications) seems to have been made when communication was slower and there were several different schools and approaches.

ijk 12 minutes ago | parent

There is definitely a kind of monocrop problem in some fields, where it seems like having a very diverse spread of academic investigation is needed to have enough diverse traces through the search space. And globalization has been flattening that.

qup 52 minutes ago | parent

> Before injecting this cocktail into your bloodstream, would you want to know that there is at least one human cancer expert who understands the mechanism behind this cure?

No. I'm gonna die, my man.

This guy might have the highest IQ on the planet, but it's clear he hasn't spent much time around average people.

This argument is so silly against reality, and already, almost nobody understands the things they put in their body to any significant degree, beyond the effect produced.

Will I take a cancer cure that no human understands? Yes. And so will billions of others. Just needs to cure cancer, that's nearly the only requirement.

erichocean 49 minutes ago | parent

It's science (understanding) before engineering (efficacy).

The most common Science™ failure mode.

qup 43 minutes ago | parent

I agree, if you mean he's prioritizing that.

But since when do we call for a stop to figuring out new things? We don't want a cancer cure unless we understand it?

N people should die because...math is cool for humans? Or?

chpatrick 44 minutes ago | parent

What if it takes your five years to live down to two in horrible agony?

qup 42 minutes ago | parent

Then it won't be a cure for cancer

Tao called it a cure, see the thing I quoted.

chpatrick 40 minutes ago | parent

"its model predicts [...] will kill cancer cells"

qup 37 minutes ago | parent

> Before injecting this cocktail into your bloodstream, would you want to know that there is at least one human cancer expert who understands the mechanism behind this cure?

It's a cure

chpatrick 5 minutes ago | parent

...his point is we don't know if it is a cure or not, and it would be good if humans had an idea instead of just having to take the AI's word for it.

Fraterkes 23 minutes ago | parent

I think this is just an embarrasingly bad faith / low effort way of engaging with the argument.

pixl97 35 minutes ago | parent

I mean stuff like this happens in trials without AI too.

gpt5 37 minutes ago | parent

And to be fair - that how medicine works today. We don’t really understand what goes into our body, so that’s why we do clinical trials. And sometimes we discover adverse side effects years and decades after a drug has been released.

qup 34 minutes ago | parent

Yes, and that isn't the model's fault any more than it would be for a human.

That's what the trials and all are for.

Who cares about understanding it, in the face of efficacy?

I want to understand everything; I think AI will help that happen, not hinder it.

All the arguments about the future mathematicians are imagined, and emotional.

alansaber 32 minutes ago | parent

Ironically this is one of the worst counterexamples he could have selected.

mahieddine 8 minutes ago | parent

If you read all the questions asked by Terrance you would have understood what he is thought behind that question "Could the AI solution to the prompt be somehow misaligned by exploiting a weakness in the trial process?"

He is not talking about a cure that works and that no one understands, he is talking about an AI making its way out of the trial just to get to phase 3...

dekhn 14 minutes ago | parent

not just clinical trials- there is an enormous amount of in-vivo model study before the molecules go into people.

merely-unlikely 8 minutes ago | parent

Not only that, but also those clinical trials often have low sample sizes. Trials involving only a few hundred patients, or even fewer, are pretty common.

vishnugupta 32 minutes ago | parent

Mathematicians inhibit and explore a world that is completely made up and exists only in abstract.

I wonder if this makes them slowly get disconnected from the lived realities of billions of ordinary people.

alansaber 31 minutes ago | parent

How could a theoretical mathematician not be massively disconnected from the reality of life for the ordinary person? We usually celebrate their quirks until they come into conflict like this.

qup 27 minutes ago | parent

I agree, how could he --also being so smart.

It's a good reason not to take his advice about the real world--like how to manage AI's trajectory.

The cancer example illustrates this gap perfectly. He thoughtfully crafted the point, and defeated himself in argument.

Unless it was a move?

ks2048 24 minutes ago | parent

When thinking about math, Tao is in another world unfamiliar to us. But, he grew up in our world and is a professor in our world and if you listen to him, seems like a pretty normal guy. I think he just made a bad analogy here.

mportela 32 minutes ago | parent

Agreed. IIRC the mechanism for anesthesia in unknown to this day. In fact, medicine as a whole is very pragmatic and time and time again prefers using techniques with unknown mechanisms but proven results than waiting for a reasonable scientific explanation of what’s going on.

qup 29 minutes ago | parent

As logic would dictate--particularly for people who aren't the highest IQ guy on the planet.

Half of people are below average! They understand nothing at the level that Tao means. Literally nothing.

cjbgkagh 14 minutes ago | parent

Perhaps I'm in the lower half but I do not understand what point you're trying to make. Are you saying that as some higher plane of understanding Tao is actually correct? My thinking is that a simple counterexample would be sufficient - i.e. are there medications that people use for which the mechanism is not understood? There are many such examples as others have given in this thread.

qup 10 minutes ago | parent

Logic would dictate that medicine should be pragmatic and accept working cures that aren't understood.

If people had to understand everything that worked, most people could not really engage with anything.

If the requirement is just that one human, somewhere, understand it--how is that different from AI?

CrimsonRain 5 minutes ago | parent

Plenty of medicine... Not a single human on earth knows how they work. Now what?

delusional 31 minutes ago | parent

The problem with his argument is that he put the cart before the horse. He presupposes we've found and validated a cancer cure, but at that point any rational person would accept said cure. The moral quandary is how you are going to validate it against all the other possible candidates, when you don't have a coherent rationale for it to work.

qup 17 minutes ago | parent

What makes that quandary the moral variety?

Not understanding a mechanism doesn't make me, or the mechanism, good or evil.

We just treat it like all the other cures right?

willmeyers 31 minutes ago | parent

I think his argument is more "Could the AI solution to the prompt be somehow misaligned by exploiting a weakness in the trial process?" So an AI agent could game (lack of a better word) the process and produce something that may cure cancer, but misses something else.

Also, a large percentage of Americans were against a vaccine for COVID (which is dumb obvisouly)... so, it's not crazy to imagine people rejecting any cure made by an AI.

bbor 28 minutes ago | parent

You're right on -- the point is an alignment point in a talk that only uses "alignment" in a completely different sense than it usually is, which is incongruent at best. It's gonna lead to a way bigger backlash among laypeople/policy makers/non-expert stakeholders than the rest of the talk will lead to new growth, combined :(

qup 22 minutes ago | parent

> Also, a large percentage of Americans were against a vaccine for COVID (which is dumb obvisouly)... so, it's not crazy to imagine people rejecting any cure made by an AI.

Plenty of people will reject all AI things, fully agree.

But you mischaracterize COVID history. People were not again a COVID vaccine, by and large. They were against a rushed vaccine. They were against a vaccine without human trials. They were reluctant to guinea pig mRNA vaccines. And they opposed forced/required vaccinations.

Those are all reasonable takes. And depending on the reasoning, I can even see being anti-AI. I think a lot of spiritual people will land there, and that belief system makes their choice logical.

And if you've seen any of the Fauci stuff recently, you'll know it wasn't dumb at all.

ramraj07 21 minutes ago | parent

Do you think the current clinical trial process has not been gamed close to the edge of uselessness ?

Do you know about the fiasco with the Alzheimer’s drug that has collectively cost humanity hundreds of billions?

I don’t see how an indecipherable AI based cure can be more misaligned.

Fraterkes 29 minutes ago | parent

I don't know how to word this in a way that won't get me into a pointless semantics argument, but the word Cure in the slides is clearly used to mean "substance intended to be (but not necessarily confirmed to be) a cure". If you think it's badly worded that's fine, but ostensibly the point here's not to "win" the argument game, but to get his intended point and engage with that.

leoqa 14 minutes ago | parent

The above commenter has the same allegory- most “users” of math don’t care about the body of work behind it; only the consequence of it being proved is the fact that matters.

asdfologist 13 minutes ago | parent

But the slide says it passes a stage 3 trial. Surely many dying patients would kill for the opportunity to take the drug.

Fraterkes 4 minutes ago | parent

Many people would, many wouldn’t. The comment I’m responding to casts the decision as so uncontroversial that even asking the question is inhererently damning.

shakaijin 11 minutes ago | parent

Beat me to it. It is sad to see that a lot of the people commenting lack good reading comprehension. Or maybe it is that they just want to be dismissive of something they don't like, or just for the sake of it.

I would totally take the mysterious drug if it was clinically tested and shown to be reasonably effective. But that is not the premises presented here.

asdfologist 8 minutes ago | parent

Wrong: the slide says "the cocktail indeed passes a stage 3 trial." Be careful before you accuse others of bad reading comprehension.

dekhn 9 minutes ago | parent

No, it doesn't mean "intended to be". "While nobody truly knows how this cocktail was found, this model prediction is confirmed in Lean, and the cocktail indeed passes a stage 3 trial".

My own pointless semantic argument: we typically don't use the word cure when we talk about cancer. Instead, we use the term "complete remission". Many people who were thought to be cured then developed cancer decades later that was genetically derived from a small remaining population of cancer cells that were not eliminated in the original "cure". The word is a shibboleth for not being familiar with cancer medicine and treatment.

ekjhgkejhgk 26 minutes ago | parent

> but it's clear he hasn't spent much time around average people.

Have YOU? It's obvious to me that his example is a rhetorical device which you're taking literally. Do you also realize he's not talking about an actual cocktail? You need to get a diagnosis ASAP.

qup 14 minutes ago | parent

I own a bar, so...yes, I have. More than my fair share.

And yes, that made the cocktail distinction easy for me--it was right in my area of expertise, to rule out one variety.

If the smartest guy on the planet forms his own argument, don't you think it oughta be a good one? Pretty convincing?

pelagicAustral 22 minutes ago | parent

> t's clear he hasn't spent much time around average people.

You haven't spent too much time around academics then. These people more often than not have not spend a single minute talking to the layman.

qup 20 minutes ago | parent

You agree with my thought, but you think I'm naive to believe it?

ramraj07 20 minutes ago | parent

We don’t even know how acitaminophen works, thousands get their livers destroyed every year from it when alternatives exist, and we are yet to ban it. So how is all of the new reality any different?

1970-01-01 9 minutes ago | parent

Funny enough, it is a good argument with just a sprinkle of reality for context: Assume effective alternatives to this cocktail exist. Assume you had access to these effective alternatives. Can this be combined with other drugs? Surgery? You say you just need to cure it. You must consider the deeper mechanisms at play to consider all the possible options for living.

vluft 50 minutes ago | parent

page 20 ("A thought experiment on alignment and understanding") is perhaps not likely to quite induce the reaction in most people that Mr. Tao expected.

bbor 30 minutes ago | parent

You described my point much better -- totally agree. It also seems he maybe isn't aware of the nature of experimental drugs, which are often given to patients with serious/terminal conditions before they'd otherwise be approved...

diath 49 minutes ago | parent

> Before injecting this cocktail into your bloodstream, would you want to know that there is at least one human cancer expert who understands the mechanism behind this cure?

> Or a human mathematician who understands the mathematical model used to locate the cocktail?

If we're being fair to AI - it contains collective knowledge from all fields, which means it's probably less likely to miss something that a human would.

chaosmanage 49 minutes ago | parent

The cancer arguement on slide 20 is pretty weak. I first need to be alive in the long term to worry about the long term effects. If I had terminal cancer I'd gladly take an AI developed 'cure'.

There are still a lot of treatments/medicines in medical science where we dont know 100% the real reason as to why it does what it does but we still prescribe them because the intended effect is what we are interested in.

Loughla 43 minutes ago | parent

I'm currently on two fairly common medicines that have, in the first paragraph when reading about them, "doctors are unsure of the specific action, but it is thought that [medicine does x to y]"

If I'm terminal with cancer, I'll inject whatever if it can cure that.

alansaber 24 minutes ago | parent

Exactly, we only get to run risky clinical trials because patients are 100% desperate and know they are likely to die otherwise.

xqcgrek2 46 minutes ago | parent

Man with a cozy and soon to be irrelevant sinecure grasping at straws.

It turns out research math was puzzling solving and we rewarded idiot savants.

p11p 30 minutes ago | parent

Schadenfreude is not a life-affirming feeling my dude. I wish you the best.

123ha 28 minutes ago | parent

/r/singularity is brigading this submission.

esafak 6 minutes ago | parent

Are you going to say that of every other white collar job, since most are likely to be automated? He was problem solving with Erdos at age eight. What were you doing? What do you do now?

theturtletalks 44 minutes ago | parent

I just watched Primeagen’s video on this and Tao’s point is that juniors no longer have the path of solving a proof to earn Field’s medals. He also argues that the community part is being hurt by AI discovering proofs because in the past people used to get invite to talk and collaborate. Now all that is being taken away. The community must adapt because Pandora’s box cannot be closed.

Prime also mentioned that software development is different. In Software development, the product is what you’re building towards, so the means to get there can be disrupted without the industry being cannibalized.

In math research, the process is the product. You take away the researching part and not much is left. But my question is, these math proofs OpenAI released, will math shift to actually using the proofs to change the world instead of just finding new ones?

delusional 34 minutes ago | parent

Primeagen is a youtube reaction guy. You may as well tell me what hbomberguy, Jay Leno, or Ben Shapiro had to say about it.

alansaber 27 minutes ago | parent

I mean this is funny ad hominiem but OP has a point. Academia has always massively prioritised understanding over outcomes, injecting startup culture into it is basically injecting antimatter.

pjmlp 28 minutes ago | parent

Our industry is equally cannibalised, anyone that thinks otherwise is either having too many tokens or in a privileged position.

If business can deliver the same product with a smaller team, great!

And yes this has been happening for a while, even if not everywhere.

In enterprise consulting, projects that would require a team of 20 devs on average, now have about 5.

Moving away from on-prem, managing own cloud infra to managed containers, to serverless, SaaS and iPaaS ready made products, and offshoring naturally.

All contributed to ever decreasing team sizes.

Now AI based tooling is added to that cocktail, reducing even further the team sizes.

The only folks doing well in the end, are the employees of AI companies, without moral issues contributing to the industry downfall, because the CEO themselves aren't the ones coding and pirating human culture.

guhidalg 6 minutes ago | parent

Read the second to last slide. What we need now is *imagination*. You assume the need for new software is fixed and that AI is going to satisfy that need with fewer humans (lower cost), but by lowering the cost we can increase the supply of software!

That means software engineers better start getting creative. If you think your job is to wait for a PM to assign you a well-written researched ticket, you're done. Your job is now to figure out how to make these machines (computers) do whatever we need them to do safely, quickly, at scale, and correctly by applying all your knowledge of computer science and the engineering field of software engineering to an AI prompt.

pfdietz 5 minutes ago | parent

> Tao’s point is that juniors no longer have the path of solving a proof to earn Field’s medals.

This is a "you" problem for the math establishment, not a problem for the AI companies.

qwerty2020 44 minutes ago | parent

I'm learning so much about specific vs. generalized intelligence through this entire ordeal.

alansaber 25 minutes ago | parent

Exactly. I've never thought as much about metacognition nearly as much as I have up until this point, for better or worse.

gste 42 minutes ago | parent

> Using AI to find and highlight new principles, methods, or insights, rather than merely new proofs.

I would have assumed that, by producing new proofs, the AI has either validated existing principles, or discovered new ones? Isn't that worth studying?

Are mathematicians complaining that reviewing AI's proofs is not as fun as writing your own? Try being a programmer... welcome to our world!

If AI lacks imagination and is not discovering new principles, then it's doing us a favour: it's crossing out the problems that don't need new principles. So the problems/conjectures that are still left are the more interesting ones.

delusional 40 minutes ago | parent

Has the world gone mad? In which universe would you get a mathematical model to produce a tonic of random chemicals that optimize said mathematical model, put that through stage 3 testing, and only THEN ask if you want to inject this into yourself. My Guy, you just did clinical testing on fucking humans for phase 3, it's a little late to consider the moral ramifications of the analysis-experiment dichotomy.

The real example is that you ask ChatGPT for a novel cancer cure, and it spit out some random chemicals, probably including bleach. Do you inject that into cancer patients that have no other hope? No, you don't. You absolute charlatan.

samuelknight 40 minutes ago | parent

Slide 12 and 13 sum up my conclusions from the Oct 8 100+ reactions to 100+ solutions. Several reported OpenAI drop included answers put a wrap on problems they had been working for years. Several said that they have to completely rewrite grant requests that they had just submitted. Others described learning of the solutions problems they had been working on like losing an old friend or a lover. The general sentiment was to bemoan the loss of a field, as if it would have been better be born in the early 20th century and conclude their career arc before reaching this point. My take away is that the field needs to get it through their heads that their old problems are no longer ambitious, and that their job in the short term is to find the new frontier.

One idea Terrance Tao conjectures, which is highly doubtful, is that spamming the AI button will solve open problems without producing insightful new methods. But the OpenAI drop would seem to disprove this. The sub O(nlogn) proof for DFT for example violated very old human assumptions. Decades of work in the field was incremental progress on sub optimal method that nobody questioned hard enough. More generally, we should always be able to go back to a super-human AI and say, "Attack this problem, but don't use a method tried before."

gpt5 26 minutes ago | parent

Software engineers are primarily outcome-oriented.

Mathematicians are primarily understanding-oriented.

Leveraging AI to tackle new frontiers without true understanding converts mathematicians to engineers.

math_dandy 34 minutes ago | parent

From the slide Beyond Problem Solving:

"Reaching these lighthouses [resolutions of open problems] prematurely by automated tools can disrupt the exploration of the paths not taken, and sterilize the surrounding field."

This crucial issue is centered in mathematician psychology and the incentive structure of academic/institutional mathematics worldwide. For mathematics to flourish going forward, we will need to realign our brains to think differently about the nature of mathematical progress. And we need to reorient our institutional incentive structures towards the promotion of meaningful mathematical progress itself rather than targeting proxies that are no longer faithful.

Regardless of the precise nature or the causes of the "sterilization" Tao refers to, we (the mathematics community) can only rely on ourselves to repair it. Though, since it will involve fundamental change at the level of ossified academic institutions with many stakeholders and divergent vested interests, any such repair will be slow, frustrating, controversial, and lacking any guarantee of success.

bbor 34 minutes ago | parent

Just a ~~few~~ ton of things (sorry!), with the upfront caveat that Tao is a hero who's trying his damndest:

1. The use of semi-ugly slides to communicate this is just perfect and quite heartwarming, but it does highlight my main criticism of the mathstadon version of this thesis: he's myopically focused on mathematics as he has practiced it, rather than mathematics as a ~2400y old academy. Like, "stable for almost a century" sounds impressive, but should be a pretty obvious red flag in hindsight!

2. Glossing over "objective verifiability" feels like another place where he's ignoring a ton of relevant philosophy for no clear reason -- yes, mathematics is the only academy based in pre-conscious cognitive facts about our processing of time and space, but that's not the end of the story on "objectively verifiable". To say the least! He hedges with "broad consensus" which doesn't need to be absolute, but that seems to be not only dismissing a highly relevant question, but even implying that he might be unaware of it. I doubt he is, but still: not great.

3. Who is this for...? Why is an explanation of Lean needed in a talk given at CalTech? I suppose he's welcoming his role as a bit of an influencer, there?

4. Re:the focus-on/centrality-of 'highly digitizable' as a unique class of task that applies to mathematics in particular, I must sadly trot out the increasingly-common trop: Yudkowsky called it... https://intelligence.org/files/IEM.pdf

5. "the space of mathematical problems remains infinite" is, again, ignoring really important philosophy around academies as social structures, built for human means. Mathematics is only infinite if we decide that all knowledge is useful (the quintessential example being 'counting the grains of sand on a beach'). Not really important in the first place, but another worrying case of the above.

6. Problem solving is the goal of mathematics; he has a completely valid point here (that we shouldn't throw AIs at unsolved problems in bulk and thus lose human expertise), but it's obscured by the use of "[open] problem" being a too-technical one. IMHO. Slide 16 fails to disabuse me of this notion.

7. Slide 18 is describing the differences between functions and systems, and is arguably even talking about assemblages.

8. If we're gonna explain lean up-front, it feels like a baffling choice to throw the "maybe AI will solve cancer but use it to secretly plot to kill us all" slide in there. It's also already lead to misunderstandings and backlash on Reddit, where 'yes we want to not die of cancer!' is a pretty convincing counterpoint (if a ultimately a subtle strawman, ofc). It's also quite distinct from the rest of the talk.

As always, the best part of any Tao publication is his ability to inspire and rally and organize. I think Math 5.0 will indeed be a matter for creativity! Hopefully the IE levels off before we cease to be helpful in that capacity...

math_dandy 13 minutes ago | parent

Regarding 6., that we shouldn't throw AIs at unsolved problems in bulk and thus lose human expertise. I think that ship has well and truly sailed. AI will continue to be thown at all manner of unsolved problems, and at an increasing rate - by commercial labs, by individual researchers, and by academic research teams. The mathematical community needs to establish paths to meaning, progress, and growth of human expertise in a world where AIs will by default be thrown at every unsolved problem.

123ha 34 minutes ago | parent

Another example that people should not use medical analogies to illustrate a side point: Discussion boards will focus on the completely irrelevant side point to drown out the renewed AI caution that they do not want to hear.

Avicebron 32 minutes ago | parent

> The future of mathematics — “Math 2.0” — will require both expanding the research frontier, while simultaneously decentering the traditional role of problem solving.

Seems to be the crux of the argument, but "use your imagination" isn't a great thing to tell people who are looking at degree irrelevancy, concerned about getting tenure or a research position. How do we measure if someone is a good mathematician or not, if they are one of the sanctioned few who get access to the biggest AIs?

alansaber 29 minutes ago | parent

This consolidation of power is precisely why there is a need for open model development, and exactly why frontier labs have been lobbying hard to abolish them.

alecst 29 minutes ago | parent

Putting aside the cancer question: I still don't understand how TT seems to be fixated on what models can do today instead of tomorrow. It's realistic and even conceivable that the models will also become better at explaining and presenting proofs too. Maybe he's not emotionally ready to accept that there may not be a future where his (and to some extent, my) skills are relevant and valued. It breaks my heart. I hope I'm wrong, but it feels like we've run out of higher ground to run to.

dzink 17 minutes ago | parent

I think a better analogy would be conducting a marathon in a fog. If you can't see the path of the proof, how do you know it is completely true in all scenarios? If you can't see whether the AI runner ran through every part of the race, how do you know it didn't draw hallucinated shortcuts in the parts where humans can't see? Or worse, create obscurity and blow smoke to hide the shortcut section? If the same AI was to guide the last living humans to a star, because it found a path clear of danger, could you trust it to get in that ship? Or did it just forgot mentioning an asteroid belt the ship is not built to navigate? Truth is verifiable truth that multiple parties can agree upon. Can you trust with your life something you can't verify?

Tanjreeve 16 minutes ago | parent

It's quite noticeable how when Terence tao was sounding pro-AI the sentiment was much more positive and he was being held up as an authority to listen to. Then he puts out some limitations of AI in a presentation about how to work with it as an expert and suddenly on HN he is just some out of touch killjoy trying to hold back progress etc.

dekhn 15 minutes ago | parent

I work in drug discovery and AI and his slide about cancer medicine isn't very well informed. We have models and narratives about how drugs work, but they are woefully incomplete.

I ask nearly every doctor/researched in the medical field: if you had a AI-created drug that tremendously improved cancer treatment outcomes for your patient, would you hesitate to prescribe it because nobody understood how it worked? I have yet to hear "yes, I would hesitate", most people say "it would be cruel to deny a person a treatment that worked".

I think Tao is focusing too much on second order effects of AI on math and other fields; humans are terrible at reasoning about second order effects, especially ones that are happening dynamically, in real time, using the most advanced mathematical models the world has yet created.

gste 11 minutes ago | parent

The effect of the AI-created drug is saving someone's life.

The effect of the AI-created proof is a mathematician abandoning years of research, losing grants, awards, ruining their career, etc.

The only difference here is our emotional reaction!

djierardi 7 minutes ago | parent

In medicine, or drug discovery more generally, there's FAR too little empirical data for training of ML generally. See OpenAdmet. The kickback to "oh but yeah cancer" is currently just hype. DeepMind has pivoted to this realm but has no demonstrable improvements. For the typical phase 1-2-3 pipeline of drugs, stretching many years, there's not yet any demonstrable improvements.

peter_d_sherman 6 minutes ago | parent

>" “Ablation studies”: taking an already proved theorem and seeing whether it can still be proved after

removing some key theories or inputs

(e.g., finding an elementary proof for a result currently only provable by non-elementary means)."

As usual, Tao is brilliant in all that he researches, all that he writes about.

I chose the above statement (which is brilliant, in and of itself!) to comment on, because it leads to the following idea:

There there exists, or should exist, a dependency map in the fields of not only Mathematics, but also of Computer Programs/Software, Engineering, and even a seemingly non-related field: The Law...

In other words, how do we get from the simplest of axioms or foundational things (aka "first principles", aka "self-evident truths") to much more complex entities?

In Law for example, how do we go from the simplest of historical legal constructs to the most complex of the most complex Supreme Court cases?

You see, there is, or should be a map, you could call it a dependency map, you could call it a dependency graph, which shows more and more abstract/complex mechanisms/things/assertions/statements/truths/functions which is mapped back to , that is, dependent on various chains, various stackings, various "stacks" of simpler ones.

In Engineering, for example, how do we get from the simplest of machines to the most complex of machines? What simpler machines and/or sub-components (aka "dependencies", aka "subcomponents") are required to build it, and how do those simpler machines work, and what's the dependency graph or map for their subcomponents?

More generalized, if we have something of complexity, then how do we get there, step by step, from individual subcomponents, individual inputs, individual proofs, individual software systems, step by step?

What is the map of those dependencies?

Note that in some systems, Math proofs, for example, there may be different paths which can be traversed to get to the same destination.

Ablation Studies could be thought of in Travel, in Geography as "if I cannot take one, or a specific set of routes to get to a place, can I still get there?"

A simple example would be in Google Maps, where you'd like to drive somewhere, but you'd like to avoid tolls. Is the route still traversable while avoiding tolls? Well, that's an example of one constraint. In Ablation Studies, you might wish to remove a bunch of routes with whatever criteria or characteristics , i.e. muddy roads, roads that have characteristic X, roads that do not have characteristic Y, etc., etc.

Getting back to Math, specifically proofs, it would be great to create a dependency map/graph of all of them, and then try removing inputs (aka, paths to them, dependencies on other mathematical proofs/objects that they may have) and see if they are still reachable.

In software, when we desire the tightest, cleanest, source code, the above is related to refactoring.

In the future, I'd love to see dependency maps/graphs (call them whatever you will) for not just Mathematical Proofs (although I'd love to see that too!), but also in such diverse subjects as Science, Engineering, Programming/CS, and even the Law!

Because they should exist in all of those subjects!

Anyway, another great piece of work by Terrence Tao!