25 points hnburnsy 1 hour ago 10 comments
ChrisArchitect 1 hour ago | parent
Related:
GLP-1 may slow biological aging
xnx 39 minutes ago | parent
Many here have expressed skepticism at GLP1s because they don't require the personal discipline of caloric deficit and might have unknown side effects.
So far, all the unknown side effects I've read about have been like this.
andreshb 27 minutes ago | parent
Lawsuits claiming Ozempic, other GLP-1s led to blindness become second mass litigation over the drugs
https://www.reuters.com/legal/government/lawsuits-claiming-o...
ipsum2 26 minutes ago | parent
This is from a year ago. Millions of people are on GLP-1s, there's definitely not a mass blindness that's ongoing.
declan_roberts 18 minutes ago | parent
Not to mention the first people on these drugs were type 2 diabetics who are the exact group that's at risk for NEON.
Think of all the things they're not gonna be at risk for, not being diabetic now.
annzabelle 13 minutes ago | parent
N of 1, but I had serious low drive/motivation side effects from Wegovy. Everything enjoyable became less enjoyable, from alcohol, to running, and after a couple of months, even getting out of bed. I lost weight slower than I had previously with old school calorie counting (most of which I have kept off to this day). Within a couple weeks of getting off it I was back to normal.
My conspiracy theory is that a lot of people must be getting this global lowered reward sensitivity from GLP-1s but are ignoring the negative sides of that effect because they like being skinny.
lucianmarin 13 minutes ago | parent
It's not the caloric deficit, it's the insulin. Cells don't have caloric receptors, only insulin receptors. I created an info site about this. Managing your insulin have the same effects as GLP-1 meds.
metadat 2 minutes ago | parent
Why mention your info site without providing a link? It's a little frustrating to read comments like this. Thank you.